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Biomarkers for lipid oxidation. oxidative stress
Anti MDA monoclonal antibody
Suitable for immunohistocheistry. For research use only.
About malondialdehyde (MDA)
Malondialdehyde (MDA) is one of the major aldehyde derive from lipid peroxidation. MDA is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with MDA and lysine residue leads to the formation of numerous numbers of adducts, such as dihydropyridine-lysine (DHP-lysine) type derivative. This monoclonal antibody is specific for the MDA-modified protein, especially DHP-lysine type derivative.
Specifications
Clone #: 1F83
Antigen: MDA-modified keyhole-lympet hemocyanine.
Form: Frozen (100 µg/mL antibody in 10mM PBS containing 0.1% NaN3 and 0.5% BSA). Purified by Protein-A.
Application: Immunohistochemistry.
Recommended antibody concentration is 0.5-1.0 µg/mL on paraformaldehyde fixed tissue.
Specificity: MSpecific for MDA-modified protein (especially DHP-lysine).
Subclass: Mouse IgG2a(lambda)
Storage: Less than -20°C
 
Specificity of anti MDA antibody. Immunohistochemical detection of MDA-modified protein in atherosclerotic aorta.
Dr. N Shibata, Tokyo Women's Medical University.
References
1) Immunochemical detection of a lipofuscin-like fluorophore derivered from malondialdehyde and lysine.
S Yamada, S Kumazawa, T Ishii, T Nakayama, K Itakura, N Shibata, M Kobayashi, K Sakai, T Osawa and K Uchida.
J.Lipid Res. 42, p1187-1196 (2001)
2) Investigation on the Origin of Sperm DNA Fragmentation: Role of Apoptosis, Immaturity and Oxidative Stress.
Muratori M, Tamburrino L, Marchiani S, Cambi M, Olivito B, Azzari C, Forti G, Baldi E
Mol Med. 21,p109-122(2015). doi: 10.2119/molmed.2014.00158.
Product name Code Content
Anti Malondialdehyde (MDA) monoclonal antibody MMD-030n 30 µg IgG

Manufactured by NOF corporation, Japan.


How to order
Instruction manual (PDF) Technical information
[NOTICE]: Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or other use.

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